TabernanthineTabernanthine is an alkaloid found in Tabernanthe iboga. It has been used in laboratory experiments to study how addiction affects the brain. Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.PharmacologyIt is kappa opioid agonist and NMDA receptor antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptors.