TOG superfamily
The transporter-opsin-G protein-coupled receptor 'superfamily' is a protein superfamily of integral membrane proteins, usually of 7 or 8 transmembrane alpha-helical segments. It includes ion-translocating microbial rhodopsins and G protein-coupled receptors, Sweet sugar transporters, nicotinamide ribonucleoside uptake permeases,,,, and.
Families
Currently recognized families within the TOG Superfamily include:- - The Testis-enhanced Gene Transfer (TEGT) Family
- - The Mg2+ Transporter-E (MgtE) Family
- - The Magnesium Transporter1 (MagT1) Family
- - The Lysosomal Cystine Transporter (LCT) Family
- - The Ni2+-Co2+ Transporter (NiCoT) Family
- - The Phosphate:Na+ Symporter (PNaS) Family
- - The Organic Solute Transporter (OST) Family
- - The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
- - The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
- - The Ion-translocating Microbial Rhodopsin (MR) Family
- - The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family
- - The G-protein-coupled receptor (GPCR) Family
Structures
A couple of the 3-D structures available for members of the following families include:- SWEET family:
- MR family:, - high resolution structures
- PnuC family:
- GPCR family: