Substituted naphthylethylamine


The substituted naphthylethylamines are a class of chemical compounds based on naphthalene. Many naphthylethylamines are naphthylaminopropanes due to the presence of a methyl group at the alpha carbon of the alkyl chain. The naphthylethylamines are derivatives of the phenethylamines, while the naphthylaminopropanes are derivatives of the amphetamines.
There are two types of naphthylethylamines based on positional isomerism: 1-naphthylethylamines and 2-naphthylethylamines. Examples of these include 1-naphthylaminopropane and 2-naphthylaminopropane, respectively.

List of substituted naphthylethylamines

The substituted napthylethylamines include the following compounds:
Additional naphthylethylamines include 4-NEMD, centanafadine, nafimidone, naphazoline, and xaliproden. Some synthetic cannabinoids such as THJ-018 and THJ-2201 are also naphthylethylamines.

Related compounds

Some related compounds that are not technically naphthylethylamines include 1-naphthylpiperazine and its derivatives like CSP-2503, F-11,461, S-14506, and S-14671. Another related compound is 2-naphthylpiperazine. DMNPC is a 2-naphthylpiperidine.

Pharmacology

Many naphthylethylamines, like 2-naphthylaminopropane and derivatives, act as monoamine releasing agents, monoamine [reuptake inhibitor]s, and/or monoamine [receptor modulator]s. Naphthylpropylaminopentane is a monoaminergic [activity enhancer]. Some, such as 2-naphthylaminopropane and to a lesser extent 1-naphthylaminopropane, but not others, such as NPAP, are also variably potent monoamine [oxidase inhibitor]s.