Naphthylpropylaminopentane

1--2-propylaminopentane, also known as 2-naphthyl-α,N-dipropylphenethylamine, is a monoaminergic activity enhancer of the α-propylphenethylamine and naphthylaminopropane families related to phenylpropylaminopentane. It is the analogue of PPAP in which the phenyl ring has been replaced with a naphthalene ring. MAEs are agents that enhance the action potential-mediated release of monoamine neurotransmitters. NPAP is a MAE of norepinephrine and dopamine but not of serotonin. Its potency is similar to that of PPAP. As with PPAP, the -enantiomer of NPAP is more potent as a MAE. Like PPAP, it is inactive as a classical monoamine releasing agent. NPAP was developed by József Knoll and colleagues and was first described in 2001.