List of highways numbered 181
The following highways are numbered 181:
Canada
- Prince Edward Island Route 181
Chile
- Route 181-CH in Araucanía Region
Cuba
- Guanabacoa–Cotorro Road
India
- National Highway 181
Ireland
- R181 road
Japan
- Japan National Route 181
United Kingdom
- M181 motorway
- B181 road
- road
United States
- Interstate 181
- U.S. Route 181
- Alabama State Route 181
- Arizona State Route 181
- Arkansas Highway 181
- California State Route 181
- Connecticut Route 181
- Florida State Road 181
- Georgia State Route 181
- Georgia State Route 181
- Illinois Route 181
- Iowa Highway 181
- K-181
- Kentucky Route 181
- Louisiana Highway 181
- Maine State Route 181
- Maryland Route 181
- Massachusetts Route 181
- M-181
- Missouri Route 181
- New Jersey Route 181
- New Mexico State Road 181
- New York State Route 181
- North Carolina Highway 181
- Ohio State Route 181
- Pennsylvania Route 181
- South Carolina Highway 181
- Tennessee State Route 181
- Utah State Route 181
- Texas State Highway 181
- * Texas State Highway Loop 181
- * Farm to Market Road 181
- Virginia State Route 181
- Washington State Route 181
- Wisconsin Highway 181