List of highways numbered 280
Route 280, or Highway 280, may refer to:
Australia
Canada
Finland
Japan
United States
- Interstate 280
- U.S. Route 280
- Arizona State Route 280
- Arkansas Highway 280
- * Arkansas Highway 280 Spur
- Florida [State Road 280]
- Georgia State Route 280
- Kentucky Route 280
- Maryland Route 280
- Minnesota [State Highway 280]
- Montana Secondary Highway 280
- New York State Route 280
- North Carolina Highway 280
- Pennsylvania Route 280
- South Carolina Highway 280
- Tennessee State Route 280
- Texas State Highway 280
- * Texas State [Highway Spur 280]
- * Farm to Market Road 280
- Utah State Route 280