Spencer Burford

Spencer Burford is an American professional football guard for the San Francisco 49ers of the National Football League. He played college football for the UTSA Roadrunners.

Professional career

Burford was selected by the San Francisco 49ers in the fourth round, 134th overall, of the 2022 NFL draft. As a rookie, he appeared in and started 16 games.
On September 20, 2025, Burford was placed on injured reserve due to a knee injury suffered in Week 2 against the New Orleans Saints. On November 1, Burford was activated from injured reserve ahead of the team's Week 9 game against the New York Giants.