James Spence

• James Spence (sailor), Olympic sailor from the Great Britain
• James Spence (surgeon), Scottish surgeon
• James Calvert Spence, British paediatrician
• James Houston Spence, Canadian lawyer and Senator
• James MacDonald Spence, lawyer and Justice of the Ontario Superior Court of Justice
• Jamie Spence, English golfer
• James Spence, Scottish author of the 2009 book ''Silly Beggar''