Spafford
Spafford may refer to:
People
- Belle S. Spafford, American president of the Relief Society
- Gene Spafford, American professor of computer science at Purdue University
- Horatio Spafford, American religious leader and author of the hymn "It Is Well With My Soul"
- Michael Spafford, American artist
- Patricia Spafford Smith, American politician
- Suzy Spafford, American cartoonist, creator of "Suzy'z Zoo"