Solypertine
Solypertine, also known as solypertine tartrate in the case of the tartrate salt, is a drug of the pertine group described as an antiadrenergic and as also potentially possessing neuroleptic properties which was never marketed.
Structurally, it is a substituted tryptamine and a piperazinylethylindole. The drug is closely structurally related to other "pertines" including alpertine, milipertine, and oxypertine, which are also tryptamines and piperazinylethylindoles. Solypertine can be synthesized from 5,6-methylenedioxyindole.
The related drug oxypertine shows high affinity for the serotonin 5-HT2 and dopamine D2 receptors and is also known to act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals. ortho-Methoxyphenylpiperazine has been said to be a metabolite of milipertine and oxypertine.
Solypertine was first described in the scientific literature by 1962.