Pertine
The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:
Oxypertine is known to show high affinity for the serotonin 5-HT2 and dopamine D2 receptors and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.
Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.
The pertines were developed and initially described in the 1960s and 1970s.