Sodium chlorodifluoroacetate
Sodium chlorodifluoroacetate is the organofluorine compound with the formula. It is a salt formed by neutralization of chlorodifluoroacetic acid with sodium hydroxide. The compound, a white solid, is of interest as a source of difluorocarbene:
This reaction is conducted in a hot solution also containing the substrate. Diglyme is a typical solvent. The conversion of sodium chlorodifluoroacetate is proposed to start with decarboxylation, which generates the carbanion.
One set of applications is difluorocyclopropanation. Thermal decomposition of sodium chlorodifluoroacetate in the presence of triphenylphosphine and an aldehyde allows for a Wittig-like reactions In this case, is proposed as an intermediate.