Isaac Smith
Isaac Smith may refer to:
- Isaac Smith (American football), American football player
- Isaac Smith (footballer), Australian rules footballer
- Isaac Smith (New Jersey politician), United States Representative from New Jersey
- Isaac Smith (Pennsylvania politician), United States Representative from Pennsylvania
- Isaac Smith (priest), Anglican priest in Ireland
- Isaac Smith (Royal Navy officer), Royal Navy officer and the first European to set foot in eastern Australia
- Isaac Smith Jr., American minister and librarian
- Isaac C. Smith, New York sail and steamboat captain, shipbuilder, sparmaker and entrepreneur
- Isaac D. Smith, US Army general
- Isaac E. Smith, boat builder who built the first Star Class sailboats
- Isaac W. Smith (surveyor), American soldier and surveyor
- USS Isaac Smith, a merchant steamboat built in 1861 that served as a Union Navy gunboat, and later a Confederate blockade runner, during the American Civil War