| Office | Name | Date |
Prime Minister First Lord of the Treasury | Henry John Temple, 3rd Viscount Palmerston | 12 June 185918 October 1865 |
Prime Minister First Lord of the Treasury | John Russell, 1st Earl Russell | 29 October 186526 June 1866 |
| Chancellor of the Exchequer | William Ewart Gladstone | 18 June 1859 |
| Parliamentary Secretary to the Treasury | Henry Brand | 24 June 1859 |
| Financial Secretary to the Treasury | Samuel Laing | 24 June 1859 |
| Financial Secretary to the Treasury | Frederick Peel | 2 November 1860 |
| Financial Secretary to the Treasury | Hugh Childers | 19 August 1865 |
| Junior Lords of the Treasury | Edward Knatchbull-Hugessen | 24 June 185921 April 1865 |
| Junior Lords of the Treasury | Sir William Dunbar, 7th Baronet | 24 June 185921 April 1865 |
| Junior Lords of the Treasury | John Bagwell | 24 June 185925 March 1862 |
| Junior Lords of the Treasury | Luke White | 25 March 18622 June 1866 |
| Junior Lords of the Treasury | William Patrick Adam | 21 April 186526 June 1866 |
| Junior Lords of the Treasury | John Bonham Carter | 2 June 186626 June 1866 |
| Junior Lords of the Treasury | John Esmonde | 2 June 186626 June 1866 |
| Lord Chancellor | John Campbell, 1st Baron Campbell | 18 June 1859 |
| Lord Chancellor | Richard Bethell, 1st Baron Westbury | 26 June 1861 |
| Lord Chancellor | Robert Rolfe, 1st Baron Cranworth | 7 July 1865 |
| Lord President of the Council | Granville Leveson-Gower, 2nd Earl Granville | 18 June 1859 |
| Lord Privy Seal | George Campbell, 8th Duke of Argyll | 18 June 1859 |
| Secretary of State for the Home Department | Sir George Cornewall Lewis | 18 June 1859 |
| Secretary of State for the Home Department | Sir George Grey, 2nd Baronet | 25 July 1861 |
| Under-Secretary of State for the Home Department | George Clive | 18 June 1859 |
| Under-Secretary of State for the Home Department | Henry Bruce | 14 November 1862 |
| Under-Secretary of State for the Home Department | Thomas Baring | 25 April 1864 |
| Under-Secretary of State for the Home Department | Edward Knatchbull-Hugessen | 25 May 1866 |
| Secretary of State for Foreign Affairs | Lord John Russell | 18 June 1859 |
| Secretary of State for Foreign Affairs | George Villiers, 4th Earl of Clarendon | 3 November 1865 |
| Under-Secretary of State for Foreign Affairs | John Wodehouse, 3rd Baron Wodehouse | 19 June 1859 |
| Under-Secretary of State for Foreign Affairs | Austen Henry Layard | 15 August 1861 |
| Secretary of State for War | Sidney Herbert | 18 June 1859 |
| Secretary of State for War | Sir George Cornewall Lewis | 22 July 1861 |
| Secretary of State for War | George Robinson, 3rd Earl de Grey | 28 April 1863 |
| Secretary of State for War | Spencer Cavendish, Marquess of Hartington | 16 February 1866 |
| Under-Secretary of State for War | George Robinson, 3rd Earl de Grey | 18 June 1859 |
| Under-Secretary of State for War | Thomas Baring | 21 January 1861 |
| Under-Secretary of State for War | George Robinson, 3rd Earl de Grey | 31 July 1861 |
| Under-Secretary of State for War | Spencer Cavendish, Marquess of Hartington | 28 April 1863 |
| Under-Secretary of State for War | Frederick Hamilton-Temple-Blackwood, 5h Baron Dufferin and Clandeboye | 17 February 1866 |
| Secretary of State for the Colonies | Henry Pelham-Clinton, 5th Duke of Newcastle | 18 June 1859 |
| Secretary of State for the Colonies | Edward Cardwell | 7 April 1864 |
| Under-Secretary of State for the Colonies | Chichester Fortescue | 18 June 1859 |
| Under-Secretary of State for the Colonies | William Edward Forster | 25 November 1865 |
| Secretary of State for India | Sir Charles Wood, 3rd Baronet | 18 June 1859 |
| Secretary of State for India | George Robinson, 3rd Earl de Grey | 16 February 1866 |
| Under-Secretary of State for India | Thomas Baring | 25 June 1859 |
| Under-Secretary of State for India | George Robinson, 3rd Earl de Grey | 21 January 1861 |
| Under-Secretary of State for India | Thomas Baring | 31 July 1861 |
| Under-Secretary of State for India | John Wodehouse, 3rd Baron Wodehouse | 25 April 1864 |
| Under-Secretary of State for India | Frederick Hamilton-Temple-Blackwood, 5th Baron Dufferin and Clandeboye | 16 November 1864 |
| Under-Secretary of State for India | James Stansfeld | 17 February 1866 |
| First Lord of the Admiralty | Edward Seymour, 12th Duke of Somerset | 27 June 1859 |
| First Secretary of the Admiralty | Lord Clarence Paget | 30 June 1859 |
| First Secretary of the Admiralty | Thomas Baring | 30 April 1866 |
| Civil Lord of the Admiralty | Samuel Whitbread | 27 June 1859 |
| Civil Lord of the Admiralty | Spencer Cavendish, Marquess of Hartington | 23 March 1863 |
| Civil Lord of the Admiralty | James Stansfeld | 2 May 1863 |
| Civil Lord of the Admiralty | Hugh Childers | 21 April 1864 |
| Civil Lord of the Admiralty | Henry Fenwick | 22 January 1866 |
| Civil Lord of the Admiralty | Lord John Hay | 7 April 1866 |
| Civil Lord of the Admiralty | George Shaw-Lefevre | 8 May 1866 |
| Chief Secretary for Ireland | Edward Cardwell | 24 June 1859 |
| Chief Secretary for Ireland | Sir Robert Peel, 3rd Baronet | 29 July 1861 |
| Chief Secretary for Ireland | Chichester Fortescue | 7 December 1865 |
| Lord Lieutenant of Ireland | George Howard, 7th Earl of Carlisle | 24 June 1859 |
| Lord Lieutenant of Ireland | John Wodehouse, 3rd Baron Wodehouse | 1 November 1864 |
| Chancellor of the Duchy of Lancaster | Sir George Grey, 2nd Baronet | 22 June 1859 |
| Chancellor of the Duchy of Lancaster | Edward Cardwell | 25 July 1861 |
| Chancellor of the Duchy of Lancaster | George Villiers, 4th Earl of Clarendon | 7 April 1864 |
| Chancellor of the Duchy of Lancaster | vacant | 3 November 1865 |
| Chancellor of the Duchy of Lancaster | George Goschen | 26 January 1866 |
| President of the Poor Law Board | Thomas Milner Gibson | 24 June 1859 |
| President of the Poor Law Board | Charles Pelham Villiers | 9 July 1859 |
| Parliamentary Secretary to the Poor Law Board | Charles Gilpin | 28 June 1859 |
| Parliamentary Secretary to the Poor Law Board | George Byng | 22 February 1865 |
| Postmaster-General | James Bruce, 8th Earl of Elgin | 24 June 1859 |
| Postmaster-General | George Campbell, 8th Duke of Argyll | 11 May 1860 |
| Postmaster-General | Edward Stanley, 2nd Baron Stanley of Alderley | 17 August 1860 |
| President of the Board of Trade | vacant | |
| President of the Board of Trade | Thomas Milner Gibson | 6 July 1859 |
| Vice-President of the Board of Trade | James Wilson | 18 June 1859 |
| Vice-President of the Board of Trade | William Francis Cowper | 12 August 1859 |
| Vice-President of the Board of Trade | William Hutt | 22 February 1860 |
| Vice-President of the Board of Trade | George Goschen | 29 November 1865 |
| Vice-President of the Board of Trade | William Monsell | 12 March 1866 |
| Vice-President of the Committee on Education | Robert Lowe | 24 June 1859 |
| Vice-President of the Committee on Education | Henry Bruce | 26 April 1864 |
| Paymaster General | James Wilson | 18 June 1859 |
| Paymaster General | William Francis Cowper | 12 August 1859 |
| Paymaster General | William Hutt | 22 February 1860 |
| Paymaster General | George Goschen | 29 November 1865 |
| Paymaster General | William Monsell | 12 March 1866 |
| First Commissioner of Works | Henry Fitzroy | 18 June 1859 |
| First Commissioner of Works | William Francis Cowper | 9 February 1860 |
| Attorney General | Sir Richard Bethell | 18 June 1859 |
| Attorney General | Sir William Atherton | 4 July 1861 |
| Attorney General | Sir Roundell Palmer | 2 October 1863 |
| Solicitor General | Sir Henry Keating | 18 June 1859 |
| Solicitor General | Sir William Atherton | 16 December 1859 |
| Solicitor General | Sir Roundell Palmer | 8 July 1861 |
| Solicitor General | Sir Robert Collier | 2 October 1863 |
| Judge Advocate General | Thomas Emerson Headlam | 24 June 1859 |
| Lord Advocate | James Moncreiff | 24 June 1859 |
| Solicitor General for Scotland | Edward F. Maitland | 27 June 1859 |
| Solicitor General for Scotland | George Young | 11 November 1862 |
| Attorney General for Ireland | John David Fitzgerald | June 1859 |
| Attorney General for Ireland | Rickard Deasy | February 1860 |
| Attorney General for Ireland | Thomas O'Hagan | 1861 |
| Attorney General for Ireland | James Anthony Lawson | 1865 |
| Solicitor General for Ireland | John George | June 1859 |
| Solicitor General for Ireland | Rickard Deasy | 1859 |
| Solicitor General for Ireland | Thomas O'Hagan | February 1860 |
| Solicitor General for Ireland | James Anthony Lawson | 1861 |
| Solicitor General for Ireland | Edward Sullivan | 1865 |
| Lord Steward of the Household | Edward Eliot, 3rd Earl of St Germans | 18 June 1859 |
| Lord Steward of the Household | John Ponsonby, 5th Earl of Bessborough | 20 January 1866 |
| Lord Chamberlain of the Household | John Townshend, 3rd Viscount Sydney | 23 June 1859 |
| Vice-Chamberlain of the Household | Valentine Browne, Viscount Castlerosse | 23 June 1859 |
| Master of the Horse | George Brudenell-Bruce, 2nd Marquess of Ailesbury | 24 June 1859 |
| Treasurer of the Household | William Keppel, Viscount Bury | 23 June 1859 |
| Treasurer of the Household | | 8 May 1866 |
| Comptroller of the Household | Granville Proby, Baron Proby | 23 June 1859 |
| Captain of the Gentlemen-at-Arms | Thomas Foley, 4th Baron Foley | 28 June 1859 |
| Captain of the Yeomen of the Guard | Henry Reynolds-Moreton, 3rd Earl of Ducie | 28 June 1859 |
| Master of the Buckhounds | John Ponsonby, 5th Earl of Bessborough | 18 June 1859 |
| Master of the Buckhounds | Richard Boyle, 9th Earl of Cork | 23 January 1866 |
| Chief Equerry and Clerk Marshal | Lord Alfred Paget | 1 July 1859 |
| Mistress of the Robes | Harriet Sutherland-Leveson-Gower, Duchess of Sutherland | 22 June 1859 |
| Mistress of the Robes | Elizabeth Wellesley, Duchess of Wellington | 25 April 1861 |
| Lords in Waiting | James Sinclair, 14th Earl of Caithness | 23 June 185926 June 1866 |
| Lords in Waiting | Thomas Stonor, 3rd Baron Camoys | 23 June 185926 June 1866 |
| Lords in Waiting | George Pitt-Rivers, 4th Baron Rivers | 23 June 185928 April 1866 |
| Lords in Waiting | George Warren, 2nd Baron de Tabley | 23 June 185926 June 1866 |
| Lords in Waiting | Richard Dawson, 3rd Baron Cremorne | 23 June 185926 June 1866 |
| Lords in Waiting | Frederick Methuen, 2nd Baron Methuen | 23 June 185926 June 1866 |
| Lords in Waiting | George Byng, 7th Viscount Torrington | 23 June 185927 April 1884 |
| Lords in Waiting | George Byron, 7th Baron Byron | 17 July 183731 March 1860 |
| Lords in Waiting | George Harris, 3rd Baron Harris | 31 March 18604 May 1863 |
| Lords in Waiting | James Talbot, 4th Baron Talbot of Malahide | 4 May 186326 June 1866 |
| Lords in Waiting | George Phipps, 2nd Marquess of Normanby | 8 May 186626 June 1866 |
| Extra Lord in Waiting | George Byron, 7th Baron Byron | 31 March 18603 March 1868 |