Santiago Hernán Villafañe began his playing career in Argentina with Boca Juniors, with whom he debuted in the First Division. A predominantly left sided player, he is known for his tough tackling and speed.
In 2007, he joined Real Madrid from Boca Juniors, where he played as a wingback or midfielder for Real Madrid Castilla. Villafañe trained with the first team on several occasions but did not play for Real Madrid in La Liga.