Salvinorin B methoxymethyl ether
Salvinorin B methoxymethyl ether, also known as 2-O-methoxymethylsalvinorin B is a semisynthetic analogue of the natural product salvinorin A which is used in scientific research.
It has a longer duration of action of around 2 to 3hours, compared to less than 30minutes for salvinorin A, and has increased affinity and potency at the κ-opioid receptor. It is prepared from salvinorin B. The crystal structure is almost superimposable with that of salvinorin A. Structures bound to the κ-opioid receptor have also been reported.
Salvinorin B methoxymethyl ether has a Ki of 0.60 nM at the κ opioid receptor, and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its ethoxymethyl ether homologue, salvinorin B ethoxymethyl ether.
The drug was encountered online as a novel designer drug in 2020.