SSC
- A2DP
- Baby sling
- Bluetooth
- California species of special concern
- HBM-SSC
- Hull classification symbol
- IBM Secure Service Container
- International Union for Conservation of Nature
- Khatumo State
- Law enforcement in Mexico City
- MPEG-4 Part 3
- SQL Server Compact
- SSC North America
- SSC buffer
- Safe, sane and consensual
- Saint Scholastica's College, Australia
- Saint Stanislaus College
- Saint Stephen's College
- Salem State University
- San Sebastian College – Recoletos
- Sangha Supreme Council
- Santa Sabina College
- Saudi Space Commission
- Saudi Sports Company
- Scottish Submarine Centre
- Second Severn Crossing
- Secondary School Certificate
- Secondary School Leaving Certificate
- Secondary sclerosing cholangitis
- Sector skills council
- Seminole State College (Oklahoma)
- Seminole State College of Florida
- Shanghai Supercomputer Center
- Shared Services Canada
- Shared services center
- Shaw Air Force Base
- Shetland Space Centre
- Ship-to-Shore Connector
- Sierra Student Coalition
- Singapore Symphony Chorus
- Sinhalese Sports Club
- Sinhalese Sports Club Ground
- Sistema Supporto Condotta
- SkyscraperCity
- Slate Star Codex
- Society of Solicitors in the Supreme Courts of Scotland
- Society of the Holy Cross
- South Seattle College
- South Suburban College
- Southern Star Central Gas Pipeline
- Southern States Conference
- South–South cooperation
- Soviet Super Cup
- Space Systems Command
- Spatial Synoptic Classification system
- Specialized System Consultants
- Speed Skating Canada
- Spread-spectrum clocking
- St Stanislaus' College
- St Stephen's College, Hong Kong
- St. Scholastica's College, Manila
- St. Stephen's Girls' College
- Staff Selection Commission
- State Security Council
- State Services Commission
- Static synchronous compensator
- Statistical Society of Canada
- Stennis Space Center
- Strawberry Shortcake
- Stretch shortening cycle
- Student selected component
- Sulfide stress cracking
- Sunshine State Conference
- Super star cluster
- Superconducting Super Collider
- Supplementary service codes
- Swedish Space Corporation
- Swiss Science Council
- Sydney Secondary College
- Synchronous Serial Controller
- Synchronous serial communication
- Syrian Satellite Channel
- Systemic sclerosis
- Thrust SSC
- US Army Soldier Systems Center