List of highways numbered 580
Route 580, or Highway 580, may refer to:
Canada
- Alberta Highway 580
- New Brunswick Route 580
- Ontario Highway 580
United Kingdom
- A580 road
United States
- I-580
- *Interstate 580, a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
- *Interstate 580, a spur connecting Carson City, Nevada to Reno, Nevada
- *Interstate 580, a former route and now part of U.S. Route 75 in Omaha, Nebraska