List of highways numbered 381
The following highways are numbered 381:
Brazil
- BR-381
Canada
- Newfoundland and Labrador Route 381
- Quebec Route 381
- Saskatchewan Highway 381
Cuba
- Road of Jamaica
Japan
- Japan National Route 381
United States
- Interstate 381
- Georgia State Route 381
- Kentucky Route 381
- Maryland Route 381
- New York State Route 381
- North Carolina Highway 381
- Pennsylvania Route 381
- Puerto Rico Highway 381
- South Carolina Highway 381
- Tennessee State Route 381
- Virginia State Route 381