List of highways numbered 375
Route 375 or Highway 375 may refer to:
Canada
- Manitoba Provincial Road 375
- New Brunswick Route 375
- Saskatchewan Highway 375
Japan
- Japan National Route 375
United States
- Interstate 375
- Arkansas Highway 375
- Florida State Road 375
- Georgia State Route 375
- Maryland Route 375
- Nevada State Route 375
- New York State Route 375
- Puerto Rico Highway 375
- Texas State Highway Loop 375
- Virginia State Route 375
- Wyoming Highway 375