RU-27849

RU-27849, also known as 4,α-methylenetryptamine, is a serotonin receptor modulator. It can be regarded as a conformationally restricted tricyclic derivative of tryptamine or a structurally simplified derivative of LSD. This molecule was developed during structure–activity relationship studies of LSD.
It shows affinity for serotonin receptors, including for the serotonin 5-HT₁, 5-HT_1A, and 5-HT₂ receptors. RU-27849's affinities for serotonin receptors are similar to but lower than those of tryptamine and dimethyltryptamine. It shows very weak affinity for dopamine receptors and weak associated activity.
The 6-methoxy derivative of RU-27849, which is to RU-27849 as 5-methoxytryptamine is to tryptamine, appears to have much higher affinity for serotonin receptors than RU-27849 itself. A number of other derivatives also exist, including FHATHBIN, RU-28306, RU-28251, Bay R 1531, LY-293284, and LY-178210, as well as NDTDI, among others.
RU-27849 was first described in the scientific literature by 1981.