LY-178210

LY-178210, also known as LY-228729 or as 4,α-methylene-5-carboxamido-DPT, is a selective and highly potent serotonin 5-HT_1A receptor partial agonist. It has an affinity of 0.67nM for the serotonin 5-HT_1A receptor. The drug has high selectivity for this receptor over 12other assessed targets, including the serotonin 5-HT_1D, 5-HT_2A, 5-HT_2C, and 5-HT₃ receptors among others. LY-178210 is a tricyclic simplified or partial ergoline and is structurally related to LSD. It was described as a potential clinical development candidate but was not further developed and was never marketed. The drug was first reported in the scientific literature by 1990.