RU-24969

RU-24,969 is a serotonin [receptor modulator] of the tetrahydropyridinylindole group related to 5-MeO-DMT which is used in scientific research.
It is a selective agonist of the serotonin 5-HT_1A and 5-HT_1B receptors, with 5-fold preference for the latter receptor over the former. In studies, its affinities were 2nM for the serotonin 5-HT₁ receptor, 5nM for the serotonin 5-HT_1A receptor, 4nM for the serotonin 5-HT_1B receptor, 780 to 1,000nM for the serotonin 5-HT₂ receptor, and 400nM for the serotonin 5-HT_2C receptor. It also has affinity for the serotonin 5-HT_5A, 5-HT_5B, and 5-HT₇ receptors.
The drug produces MDMA-like locomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT_1A and 5-HT_1B receptors. As with other serotonin 5-HT_1B receptor agonists such as CP-94,253, RU-24,969 has also been found to increase the reinforcing properties of cocaine in animals, suggesting a role for serotonin 5-HT_1B receptors in cocaine addiction as well. The drug produces antiaggressive effects in rodents.
RU-24,969 was first described in the scientific literature by 1980.