Pitfalls in Homozygosity Mapping
Pitfalls in Homozygosity Mapping is a scholarly work by Samuel G. Jacobson, Isabel Hanson, Edwin M. Stone, and Val C. Sheffield, published in 2000 in ''American Journal of Human Genetics''. The main subjects of the publication include inbreeding, disease, Identity by descent, homozygosity, genetic mapping, haplotype, Quantitative genetics, gene, consanguinity, polyploidy, Runs of Homozygosity, genetics, locus, allelic heterogeneity, allele, copy-number variation, biology, Mendelian inheritance, and Disease gene identification. Homozygosity mapping provides a rapid means of mapping autosomal recessive genes in consanguineous families by identifying chromosomal regions that show homozygous IBD segments in pooled samples.