Phenatine
Phenatine, or phenatin, also known as N-nicotinoylamphetamine and sold under the brand name Fenatine, is a psychostimulant of the amphetamine family which was developed and used in the Soviet Union. It was used in the treatment of depression, narcolepsy, post-encephalitis sequelae, alcoholic psychoses, asthenia, and other conditions.
Chemistry
Phenatine is a condensation product of amphetamine and nicotinic acid. It was first described in the scientific literature by 1955.
Pharmacology
Phenatine is described as having effects analogous to those of amphetamine. Phenatine was also said to enhance physical and mental performance. However, the drug was described as being a milder stimulant than amphetamine whilst supposedly being superior to amphetamine and other stimulants in various respects. It was claimed to be much less toxic than amphetamine, to have hypotensive rather than hypertensive effects, and to have reduced rebound effects and addictive potential.
Analogues
An analogue is methylphenatine. Another analogue is pyridoxiphen, the condensation product of amphetamine and pyridoxine. Other relatives may include thiophenatine, propylphenamine, and phenylphenamine. Further analogues of phenatine and pyridoxphen include gamofen, alafen, and pabofen, an intermediate in the biosynthesis of folic acid ), all of which show distinct pharmacological activity.