| Name | Life | Comments | Reference |
| Michael IV the Paphlagonian | 1010–1041 | A Byzantine emperor who had frequent tonic-clonic seizures since adolescence. The seizures were interpreted at the time to be demonic possession as punishment for his sins. His royal entourage were alert to signs of an impending seizure and tried to hide the emperor when he was ill. | |
| Pedro I of Brazil | 1798–1834 | Founder and first emperor of the Empire of Brazil. There are many accounts of him having seizures throughout his life, just like his sister Infanta Isabel Maria of Braganza. One author describes them happening as early as 1811, when he was thirteen years old. | |
| Hans Ulrik Gyldenløve | 1615–1645 | Illegitimate son of Christian IV, King of Denmark and Norway, Hans Ulrik was an officer in the Danish Royal Navy and the commander of a royal castle, the Kronborg. He was prone to epileptic incidents, and during a state visit to Spain with his father's ambassador in 1640, he had a seizure shortly after a bullfight. He had to be sent home to Denmark. | |
| Ivan V Alekseyevich | 1666–1696 | Older half brother of Russian Tsar Peter the Great. Ivan V was feeble-minded, epileptic, and half-blind. Would have never become Tsar except for the support of his sister Sophia, who wanted to become regent over him. His sister, with the military backing of the Streltsy, made Ivan V rule as co-tsar with Peter I . | |
| José Antonio Páez | 1790–1873 | Former President of Venezuela Statesman and Military Commander who fought in the Venezuelan War of Independence against Spain for Simón Bolívar. He had epilepsy also while a battlefield Commander. | |
| Pope Pius IX | 1792–1878 | Had childhood epilepsy. | |
| Francis Libermann | 1802–1852 | A Jew who converted to Christianity and studied for priesthood. Epilepsy prevented his ordination for many years. | |
| Ida McKinley | 1847–1907 | First Lady of the United States from 1897 to 1901. Her epilepsy started in adulthood and was to become quite disabling and inconvenient. As was normal for the time, great efforts were made to keep this secret. Her husband, William McKinley, would cover her face with a napkin when she had symptoms at dinner parties. | |
| Vladimir Lenin | 1870–1924 | First Premier of the Soviet Union. Lenin's final year was characterized by neurological decline and loss of function. In his last few months, he developed epilepsy. His seizures worsened and he died in status epilepticus, which had lasted 50 minutes. | |
| Caligula | AD 12–41 | Roman Emperor. Suetonius states that "As a boy he was troubled with the falling sickness , and while in his youth he had some endurance, yet at times because of sudden faintness he was hardly able to walk, to stand up, to collect his thoughts, or to hold up his head." | |
| Prince Erik, Duke of Västmanland | 1889–1918 | The youngest son of Gustaf V of Sweden. | |
| Prince John of the United Kingdom | 1905–1919 | The youngest son of King George V, John had epilepsy from the age of 4 until his death after a seizure aged 13. John's epilepsy, along with intellectual disability and possibly autism, led to his living most of his life at York Cottage on the Sandringham Estate away from visitors who were not family members. | |
| Rabbi Lionel Blue | 1930–2016 | A rabbi and broadcaster, best known for his contributions to "Thought for the Day" on BBC Radio 4's Today program. His epilepsy was diagnosed when he was aged 57 and is successfully controlled with medication. | |
| Dave Longaberger | 1934–1999 | A businessman and founder of The Longaberger Company, makers of handcrafted maple wood baskets and accessories. He overcame epilepsy and a stutter, eventually graduating from high school aged 21. | |
| Joe Doyle | 1936–2009 | Joe Doyle was an Irish Fine Gael politician. He was a long-standing public representative for the Dublin South-East and served as a member of Dáil Éireann, Seanad Éireann and Dublin City Council before serving as Lord Mayor of Dublin from 1998 to 1999. He first developed epilepsy at the age of 16. He became one of Ireland's most prominent advocate's for epilepsy and was a member of the board of directors of Brainwave, the Irish Epilepsy Association, at the time of his death. | |
| Neil Abercrombie | born 1938 | The former Governor of Hawaii who campaigned for increased funding for epilepsy research. He was diagnosed with epilepsy in his early thirties. | |
| Rudi Dutschke | 1940–1979 | A prominent spokesperson of the left-wing German student movement of the 1960s. An assassination attempt in 1968, when he was shot twice in the head, left him partially blind and with frequent epileptic attacks. He drowned in the bathtub after having a seizure. | |
| Tony Coelho | born 1942 | A former United States congressman who developed epilepsy aged 16, possibly as a result of an earlier head injury. This would lead to rejection by his family and the Jesuits for "possession by the devil". He has campaigned as a congressman for disabled rights and chairs the Epilepsy Foundation's national board of directors. | |
| Eamonn McCann | born 1943 | A former Northern Ireland People Before Profit MLA from Derry and Councillor who developed epilepsy in 2006. | - |
| John Roberts | born 1955 | Roberts is the 17th Chief Justice of the United States. He was appointed to office by President George W. Bush on 29 September 2005. His first seizure occurred in 1993 which was disclosed to the Senate Judiciary Committee who confirmed him. His second seizure occurred in 2008 when he fell 5 to 10 feet onto a dock near his house. | |
| Denis O'Donovan | born 1955 | O'Donovan is an Irish Fianna Fáil politician who has served as a Senator from 1989 to 1992, 1997-2002 and since 2007. He was appointed to serve as Cathaoirleach of Seanad Éireann from 2016 to 2020 and also served as a TD for Cork South-West from 2002 to 2007. He first had a grand-mal seizure in 2020 and later episodes which left him close to death. He has since spoken publicly about his experiences in the role of an advocate. | |
| Laura Sandys | born 1964 | British Conservative Party politician. She was elected at the 2010 general election as the Member of Parliament for South Thanet. She revealed in parliament in October 2010 that she had epilepsy, but had been seizure-free for seven years. | |
| Paul Maynard | born 1975 | British Conservative Party politician. He was elected at the 2010 general election as the Member of Parliament for Blackpool North and Cleveleys. In 2010, he was appointed vice-president of the charity Epilepsy Action. | |
| Patrick O'Donovan | born 1977 | Irish Fine Gael Party politician. He was elected at the 2011 Irish general election as a Teachta Dála for Limerick. He had previously served as a Councillor on Limerick County Council from 2003 to 2011 and is a former schoolteacher. He was diagnosed with photosensitive epilepsy having collapsed in the Dáil Eireann Chamber on 29 June 2023. | - |
| Eoghan Kenny | born 2000 | Irish Labour Party politician. He was elected at the 2024 Irish general election as a Teachta Dála for Cork North-Central. He had previously served as a Councillor on Cork County Council from 2024 and is a former Schoolteacher. He was diagnosed with epilepsy during the 2024 Irish general election campaign as he had a seizure while preparing for a RTE Drivetime Radio Programme. | - |