| Rank | Combined Statistical Area | 2020 Census | 2010 Census | Change | Constituent Core Based Statistical Areas |
| 1 | [New York metropolitan area|New York-Newark, NY-NJ-CT-PA Combined Statistical Area|New York-Newark, NY-NJ-CT-PA Combined Statistical Area] | | New York-Newark-Jersey City, NY-NJ-PA Metropolitan Statistical Area Bridgeport-Stamford-Norwalk, CT Metropolitan Statistical Area New Haven-Milford, CT Metropolitan Statistical Area Trenton-Princeton, NJ Metropolitan Statistical Area Torrington, CT Micropolitan Statistical Area Kingston, NY Metropolitan Statistical Area | - | - |
| 2 | [Washington–Baltimore combined statistical area|Washington-Baltimore-Arlington, DC-MD-VA-WV-PA Combined Statistical Area|Washington-Baltimore-Arlington, DC-MD-VA-WV-PA Combined Statistical Area] | | Washington-Arlington-Alexandria, DC-VA-MD-WV Metropolitan Statistical Area Baltimore-Columbia-Towson, MD Metropolitan Statistical Area Hagerstown-Martinsburg, MD-WV Metropolitan Statistical Area Chambersburg-Waynesboro, PA Metropolitan Statistical Area Winchester, VA-WV Metropolitan Statistical Area California-Lexington Park, MD Metropolitan Statistical Area Easton, MD Micropolitan Statistical Area Cambridge, MD Micropolitan Statistical Area | - | - |
| 3 | [Philadelphia metropolitan area|Philadelphia-Reading-Camden, PA-NJ-DE-MD Combined Statistical Area|Philadelphia-Reading-Camden, PA-NJ-DE-MD Combined Statistical Area] | | Philadelphia-Camden-Wilmington, PA-NJ-DE-MD Metropolitan Statistical Area Reading, PA Metropolitan Statistical Area Atlantic City-Hammonton, NJ Metropolitan Statistical Area Dover, DE Metropolitan Statistical Area Vineland-Bridgeton, NJ Metropolitan Statistical Area Ocean City, NJ Metropolitan Statistical Area | - | - |
| 4 | Pittsburgh-New Castle-Weirton, PA-OH-WV Combined Statistical Area | | Pittsburgh, PA Metropolitan Statistical Area Weirton-Steubenville, WV-OH Metropolitan Statistical Area New Castle, PA Micropolitan Statistical Area Indiana, PA Micropolitan Statistical Area | - | - |
| 5 | Harrisburg-York-Lebanon, PA Combined Statistical Area | | Harrisburg–Carlisle metropolitan statistical area York-Hanover, PA Metropolitan Statistical Area Lebanon, PA Metropolitan Statistical Area Gettysburg, PA Metropolitan Statistical Area | - | - |
| 6 | Allentown-Bethlehem-East Stroudsburg, PA-NJ Combined Statistical Area | | Allentown-Bethlehem-Easton, PA-NJ Metropolitan Statistical Area East Stroudsburg, PA Metropolitan Statistical Area | - | - |
| 7 | [Mahoning Valley|Youngstown-Warren-Boardman, OH-PA Metropolitan Statistical Area|Youngstown-Warren-East Liverpool, OH-PA Combined Statistical Area] | | Youngstown-Warren-Boardman, OH-PA Metropolitan Statistical Area Salem, OH Micropolitan Statistical Area | - | - |
| 7 | Erie-Meadville, PA Combined Statistical Area | | Erie, PA Metropolitan Statistical Area Meadville, PA Micropolitan Statistical Area | - | - |
| 8 | Bloomsburg-Berwick-Sunbury, PA Combined Statistical Area | | Sunbury, PA Micropolitan Statistical Area Bloomsburg-Berwick, PA Metropolitan Statistical Area Lewisburg, PA Micropolitan Statistical Area Selinsgrove, PA Micropolitan Statistical Area | - | - |
| 9 | State College-DuBois, PA Combined Statistical Area | | State College, PA Metropolitan Statistical Area DuBois, PA Micropolitan Statistical Area | - | - |
| 10 | Johnstown-Somerset, PA Combined Statistical Area | | Johnstown, PA Metropolitan Statistical Area Somerset, PA Micropolitan Statistical Area | - | - |
| 11 | Altoona-Huntingdon, PA Combined Statistical Area | | Altoona, PA Metropolitan Statistical Area Huntingdon, PA Micropolitan Statistical Area | - | - |
| 12 | Williamsport-Lock Haven, PA Combined Statistical Area | | Williamsport, PA Metropolitan Statistical Area Lock Haven, PA Micropolitan Statistical Area | - | - |