Para-Iodoamphetamine
para-Iodoamphetamine, also known as 4-iodoamphetamine, is a monoamine releasing agent and serotonergic neurotoxin of the amphetamine family related to para-chloroamphetamine.
Pharmacology
Pharmacodynamics
PIA acts as a serotonin releasing agent. In animal drug discrimination tests, PIA fully substitutes for MDMA and (+)-MBDB.It also has very low affinity for certain serotonin receptors, including the serotonin 5-HT1 receptor and the serotonin 5-HT2 receptor.
PIA has been described as having either similar serotonergic neurotoxicity as PCA or as having much weaker serotonergic neurotoxicity than PCA.
Chemistry
PIA, also known as 4-iodoamphetamine, is a phenethylamine and amphetamine derivative and a para-halogenated amphetamine.Analogues
PIA is closely related to other para-halogenated amphetamines such as PCA, para-bromoamphetamine, and para-fluoroamphetamine.Iofetamine, also known as N-isopropyl--para-iodoamphetamine, is a derivative of PIA used as a radiopharmaceutical and diagnostic agent.
5-Iodo-2-aminoindane, the 2-aminoindane analogue of PIA, was an attempt to make a non-neurotoxic analogue of PIA that proved to be less neurotoxic.