Route 2 (Paraguay)
National Route Number 2 is one of the most important highways in Paraguay, which connects the two major cities in the country, Asunción and Ciudad del Este. Crossing the departments of Central, Cordillera, Caaguazu and Alto Paraná.
In 2019, the between Ciudad del Este and Caaguazú were doubled. In 2024, the duplication of of the highway between the cities of Ypacaraí and Caaguazú was completed. So, the first duplicated highway in Paraguay was created. The highway is the most important in the country, as it connects the capital Asunción with the second largest city, with Brazil and finally with the Port of Paranaguá.
Notable sites of interest
The National Museum of Natural History of Paraguay is located right next to the PY02 highway, in San Lorenzo.Distances and important cities
The following table shows the distances traversed by National Route 2 in each different department, and important cities that it passes by.| Km | City | Department | Junctions/Tolls |
| 0 | Asunción | Asunción | |
| 6 | Fernando de la Mora | Central | |
| 10 | San Lorenzo | Central | 15px PY01 |
| 19 | Capiatá | Central | |
| 29 | Itauguá | Central | |
| 36 | Ypacaraí | Central | 20px |
| 52 | Caacupé | Cordillera | |
| 71 | Eusebio Ayala | Cordillera | |
| 86 | Itacurubí de la Cordillera | Cordillera | |
| 101 | San José de los Arroyos | Caaguazu | |
| 123 | Nueva Londres | Caaguazu | 20px |
| 132 | Coronel Oviedo | Caaguazu | 15px PY08 |
| 179 | Caaguazú | Caaguazú | 15px PY13 |
| 204 | Doctor Juan Manuel Frutos | Caaguazú | 20px |
| 216 | Doctor J. Eulogio Estigarribia | Caaguazú | |
| 244 | José Domingo Ocampos | Caaguazú | |
| 250 | Juan Emilio O'Leary | Alto Paraná | |
| 262 | Doctor Juan León Mallorquín | Alto Paraná | |
| 288 | Yguazú | Alto Paraná | |
| 312 | Minga Guazú | Alto Paraná | 15px PY06/20px |
| 327 | Ciudad del Este | Alto Paraná | 15px PY07 |