Django, a gunfighter, teams up with another gunfighter named Sartana to wipe out a gang of gun-runners that have been terrorizing the citizens of Black City.
In a retrospectivereview, Howard Hughes wrote in his book Cinema Italiana that One Damned Day at Dawn...Django Meets Sartana! was "a plotless meander made on the cheap in familiar Lazio quarries." and stated that "Fidani's westerns, particularly, are notable for their stunt performer's twitching deaths, which more closely resemble electrocution or gymnastics" and finally compared the director to Ed Wood, stating that Fidani's film titles were always more imaginative than the bargain-basement films they publicise.