Obicetrapib


Obicetrapib is an experimental CETP inhibitor that is intended to treat dyslipidemia. In a clinical trial, as an add-on to statins, compared with placebo, it decreased concentrations of LDL-C, apolipoprotein B and non-high-density lipoprotein cholesterol , and increased HDL-C concentration. As of 2023, it is in a Phase III trial.

History

Obicetrapib was initially developed by Amgen as AMG-899 and was abandoned in 2017. In 2020, Amgen licensed the drug to NewAmsterdam Pharma. In 2022, NewAmsterdam Pharma licensed the drug to Menarini Group.