| Disease | Years notifiable |
| Acute flaccid paralysis | 2000–present |
| AIDS | 1986–present |
| Anaplasmosis | 2024–present |
| Anthrax | 1930–1982, 2002–present |
| Babesiosis | 2024–present |
| Botulism | 1933–present |
| Brucellosis | 1928–present |
| Campylobacteriosis | 1986–present |
| Chickenpox | 1924–1958, 1986–present |
| Chlamydia | 1991–present |
| Cholera | 1930–present |
| Clostridioides difficile associated diarrhea | 2009–present |
| Congenital rubella syndrome | 1979–present |
| Congenital syphilis | 1993–present |
| Creutzfeldt-Jakob disease | 2000–present |
| Cryptosporidiosis | 2000–present |
| Cyclosporiasis | 2000–present |
| Diphtheria | 1924–present |
| Giardiasis | 1983–present |
| Gonorrhea | 1924–present |
| Group B streptococcal disease of the newborn | 2000–present |
| Hantavirus pulmonary syndrome | 2000–present |
| Hepatitis A | 1927–1958, 1969–present |
| Hepatitis B | 1969–present |
| Hepatitis C | 1991–present |
| HIV Infection | 2000–present |
| Influenza, laboratory confirmed | 2000–present |
| Invasive Group A streptococcal disease | 2000–present |
| Invasive Haemophilus influenzae, non-b disease | 2007–present |
| Invasive Haemophilus influenzae, type b disease | 1986–present |
| Invasive Meningococcal disease | 1924–present |
| Invasive Pneumococcal disease | 2000–present |
| Legionellosis | 1986–present |
| Leprosy | 1925–present |
| Listeriosis | 1990–1999, 2007–present |
| Lyme disease | 2009–present |
| Malaria | 1929–1978, 1983–present |
| Measles | 1924–1958, 1969–present |
| Monkeypox | 2024–present |
| Mumps | 1924–1958, 1986–present |
| Norovirus infection | 2007–present |
| Paralytic shellfish poisoning | 2007–present |
| Pertussis | 1924–present |
| Plague | 1930–present |
| Poliomyelitis | 1924–present |
| Powassan Virus Disease | 2024–present |
| Rabies | 1927–present |
| Rubella | 1924–1958, 1969–present |
| Salmonellosis | 1959–present |
| SARS | 2004–present |
| Shigellosis | 1924–present |
| Smallpox | 1924–1981, 2002–present |
| Syphilis | 1924–present |
| Tetanus | 1957–present |
| Tuberculosis | 1924–present |
| Tularemia | 1930–1982, 2002–present |
| Typhoid | 1924–1952, 1969–present |
| Verotoxigenic Escherichia coli infection | 1991–present |
| Viral hemorrhagic fever | 1979–1982, 2002–present |
| West Nile virus infection | 2003–present |
| Yellow Fever | 1930–present |