No Ordinary Family

Cast and characters

Main cast

• Michael Chiklis as James "Jim" Powell, Sr. – a police sketch artist whose power is super-strength. He is nearly invulnerable, and can leap over tall buildings. When in contact with cinoxate, his powers fail. His weakness lies in finesse and agility.
• Julie Benz as Dr. Stephanie Powell – a scientist who works at Global Tech. She has super speed and an incredibly fast metabolism that allows her to heal quickly. However, when she was attacked by Lucas Winnick, an animal-like posthuman, she was injected with the Trilsetum coronis serum in an attempt to save her life. This allowed her to run faster than the speed of light, enabling time travel. She was initially working on the research of the Trilsetum coronis, the "crown jewel" plant of the Amazon Basin. She later found out that the plant shared the same chromosomes as the family's superpowered DNA.
• Kay Panabaker as Daphne Nicole Powell – Jim and Stephanie's 16-year-old daughter. She has the power of telepathy and the ability to view the memories of others. She later discovered that she could also influence the behavior of others for a short time by means of telepathic suggestion. She also develops the ability to erase memories through this method.
• Jimmy Bennett as James "JJ" Powell, Jr. – Jim and Stephanie's 14-year-old son; a teenager with enhanced intelligence. He has the ability to speed-read and comprehend large amounts of information by just reading the page. This ability gives him a photographic memory. He is also capable of learning a new language fluently in a matter of minutes. His powers extend to a form of "genius vision". When he experiences intense emotional stress, his powers fail. His enhanced intellect appears to extend his ability to handle extra-academic situations, enhanced fighting skill being an example. It is revealed that he is immune to Daphne's telepathic push.
• Autumn Reeser as Katie Andrews – a lab tech and Stephanie's personal assistant at Global Tech and comic book fangirl. She is aware of the Powells' superpowers. She is also dating the Watcher, but it is unknown to her that he had been hired by Dr. King to find out about the Powell family's abilities. Her favorite superhero is Kitty Pryde. Katie acquired telekinetic powers due to her pregnancy with Joshua's child. Katie and Joshua eventually reconnect after he returns and helps Katie deliver their baby prematurely. The baby initially appears to be stillborn, but its eyes quickly flash green and it returns to life, presumably as a result of its Trilsetum coronis DNA.
• Romany Malco as George St. Cloud – an assistant district attorney in Pacific Bay and long-time friend of Jim's. He also knows of the Powells' superpowers. He is a comic book fanboy. He sponsors and runs the crime-fighting intelligence network from his garage which he has equipped with hi-tech surveillance, tracking and computer equipment. In the season one finale, George is aboard an airplane along with 80 prisoners who are to be turned into super villains. Since George survived the crash it is presumed that he also developed super powers like the rest of passengers on the plane after crashing in the same manner as the Powells.
• Stephen Collins as Dr. Dayton King – Stephanie's boss at Global Tech and, as the series unfolds, a key figure in the Powells' super-powered universe. He is a typical Hitchcockian villain to the series. He is also in love with Stephanie Powell. In episode 14, through the security cameras, he finally learns of Jim and Stephanie's powers. In episode 16, it is revealed that he is The Watcher's adoptive father and has some sort of interest in JJ's powers. It is revealed he took the serum to heal himself after contracting cancer. In episode 20, JJ injects him with Stephanie's power cure, and King dies when the cancer returns at an accelerated rate.
• Josh Stewart as the Watcher – Dr. King's super villain enforcer and assassin, his control of people's memory allows him to return under different aliases, Will and later Joshua, when interacting with the family during his investigation of them. His powers are temporary, and without regular injections from Dr. King to maintain them, he undergoes withdrawal. He has been shown to have the abilities of telekinesis, telepathic suggestion, and an immunity to Daphne's telepathy. In Episode 11, he surrenders the injections that give him his powers in order to start a normal relationship with Katie. In Episode 16, he learns that Dr. King is his adoptive father who saved his life from a terminal illness by injecting him with the serum when Joshua was 6 years old. In the season finale, Joshua helps JJ figure out the secret to making the super powers permanent, after which Dr. King tells his "son" that Joshua should go and be with his family. Joshua returns to Katie, and, after turning Victoria away, helps Katie deliver their child.

  Recurring cast

• Christina Chang as Detective Yvonne Cho – a cop who worked at the same precinct as Jim. She was murdered by Joshua in Episode 2, shot with her own gun, off screen.
• Jason Antoon as Mr. Litchfield – JJ's math teacher, who initially suspected JJ of cheating due to his sharp change after he came back from his vacation. Later worked for Dr. King and then Mrs. X in attempting to harness JJ's powers for himself. Killed on Mrs. X's orders after repeatedly failing to get JJ's cooperation.
• Guillermo Díaz as Detective Frank Cordero. Took over Detective Cho's role after her murder. Was killed by dirty cops in Episode 19.
• Reggie Lee as Dr. Francis Chiles – a scientist who worked for Global Tech. He was murdered by the Watcher in Episode 10.
• Amy Acker as Amanda Grayson, co-counsel of George and DA of the Pacific Bay district. She seems to have a close relationship with George.
• Luke Kleintank as Chris Minor – a juvenile delinquent with a good heart, who falls for Daphne Powell and becomes her new boyfriend. She eventually tells him about her powers. He persuades her to use them to help them cut school and get time off from his boss. When her family pressures her to keep their secret, Daphne decides to erase Chris' memory of her powers. However, this also makes him forget their entire relationship.
• Jonna Walsh as Megan—Daphne's friend, who she wishes to confide her secret to.
• Katelyn Tarver as Natalie Poston – JJ's love interest, member of the "Smart People Club", good at playing chess. Her mother was murdered when she was four years old and she never knew who her father was, so she has moved around between foster homes for the past 12 years.
• Katrina Begin as Bailey Browning – alpha girl at Daphne's and JJ's high school. She has shown to take an interest in JJ after JJ's and Natalie's break-up.
• Rebecca Mader as Victoria Morrow – Vice President of Human Resource at Global Tech and another super villain. She pledged allegiance to Dr. King and has the ability to shape-shift. In Episode 13, she learned of Stephanie Powell's superpowers. In Episode 15, she appears to die in a brawl with Jim. However, it turns out later she is still alive, revived by Mrs. X, who sends her to find out more of Katie's pregnancy. In Episode 20, it is revealed that she is also in love with Joshua. She is also on the plane that spirals out of control and crashes in that same episode.
• Jean-Luc Bilodeau as Brett Martin – Daphne's schoolmate who is interested in modern art, Japanese language and sushi.
• Lucy Lawless as Helen Burton, a.k.a. Mrs. X – The CEO of Global Tech whom Dr. King works for and reports to. She is the real villain to the series and is intent on finding out the Powells' powers and the secret to permanence.

  Guest cast

• Tate Donovan as Mitch McCutcheon – was initially a series regular, but was subsequently dropped. The pilot for the Powell's airplane for their Brazil trip who is presumed dead.
• Chord Overstreet as Lucas Fisher – Daphne's boyfriend who she discovers is cheating on her when she reads his mind.
• Bruce McGill as Allan Crane – Stephanie's father who hates Jim and later accuses him of cheating on Stephanie.
• Cybill Shepherd as Barbara Crane – Stephanie's mother
• Jackson Rathbone as Trent – a boy who witnesses his house being robbed, refuses to tell the truth to the police. Daphne discovers new elements to her powers when she touches his hand and can read his past thoughts/memories re: the break-in.
• Rachel Miner as Rebecca Jessup – formerly arrested, she used her hands to emit shock-waves to create artificial earthquakes in order to steal medicines in various pharmacies to get rid of her abilities. She was also locked up by Dr. King many times. It is not known what happened to her after she has been knocked out by Joshua.
• Anthony Michael Hall as Roy Minor – Chris' father who gains super strength making him stronger than Jim after his son steals Stephanie's serum.
• Alex Solowitz as Theo Patton – a sociopathic serial arsonist who can set himself on fire; supposedly killed when a tank of sand fell on him while he was on fire.
• Jamie Harris as Reed Koblenz – a teleporter and robber who was shot and killed by Det. Cho in episode 1.
• Annie Wersching as Michelle Cotten – Dave's wife and secret art thief.
• Rick Schroder as Dave Cotten – a man who befriends the Powells after Jim saves his life.
• Billy Unger as Troy Cotten – Dave and Michelle's son.
• Conor Leslie as Chloe Cotten – Dave and Michelle's daughter.
• Jason Wiles as Mike Powell – Jim's brother who is up to his neck in debt and takes advantage of JJ's powers.
• Ethan Suplee as Tom Seeley – escaped from Santos County Correctional Facility the same place where Rebeccas Jessup and Theo Patton was arrested. He wanted payback on Dr. King. Can become fog with his powers.
• Tricia Helfer as Sophie Adler – a beautiful woman who can make men fall in love with her by way of her pheromones. Mrs. X asks her to seduce George and Jim; the plan works at first, but ultimately fails. She dies in a car explosion which was set up by Mrs. X.
• Robert Picardo as Mr. Lance – The vice-principal at Daphne and JJ's school.
• Eric Balfour as Lucas Winnick – a man with the powers of various animals who Mrs. X assigns to kill people with super powers but he later discovers that the Powells have powers and they become his next target.
• Michael Maize as Ben – a man with the power to use electricity to stop or kill people. He dies in episode 20 when his abilities backfire on him.
• Shay Carl as security guard