No Evidence for a Functional Role of Bi-Directional Notch Signaling during Angiogenesis
No Evidence for a Functional Role of Bi-Directional Notch Signaling during Angiogenesis is a scholarly work by Hellmut G Augustin, published in 2012 in ''PLOS One''. The main subjects of the publication include chemistry, signal transduction, axon guidance, Hes3 signaling axis, transcription factor, biology, Notch signaling pathway, Notch proteins, CDK8, cell biology, angiogenesis, and JAG1. The authors report here that the Notch ligands DLL1 and JAG1 are processed in endothelial cells in a gamma-secretase-dependent manner and that the intracellular ligand domains accumulate in the cell nucleus.