RRNA small subunit pseudouridine methyltransferase Nep1

RRNA small subunit pseudouridine methyltransferase Nep1 is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA -methyltransferase. This enzyme catalyses the following chemical reaction
This enzyme recognizes specific pseudouridine residues in small subunits of ribosomal RNA based on the local RNA structure.
A point mutation in the ribosome biogenesis factor Nep1 impairs its nucleolar localisation and RNA binding and causes the Bowen-Conradi syndrome.