Nader Rahimi has extensively published in the field of signal transduction by receptor tyrosine kinases in particular VEGF receptortyrosine kinases. His notable works include demonstration of differential function of VEGFR-1 and VEGFR-2 in angiogenesis, identification of lysine methylation as a novel mechanism of activation of VEGFR-2, establishing protein ubiquitination as a major pathway modulating the angiogenic signaling of VEGFR-2. He is also responsible for the discovery of multiplecell surface receptors including, IGPR-1, TMIGD1, MINAR1, and MINAR2. His work on COVID-19 resulted in the discovery of CD209L and CD209 as novel receptors and vimentin as an attachment factor for SARS-CoV-2.