Malate dehydrogenase (decarboxylating)
Malate dehydrogenase or NAD-malic enzyme is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are -malic acid and oxidised nicotinamide adenine dinucleotide. Its products are pyruvic acid, carbon dioxide, and reduced NADH.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is -malate:NAD+ oxidoreductase . This enzyme participates in pyruvate metabolism and carbon fixation. NAD-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C4 [carbon fixation|C4] and CAM plants. The others are NADP-malic enzyme and PEP carboxykinase.