Motexafin gadolinium
Motexafin gadolinium is an inhibitor of thioredoxin reductase and ribonucleotide reductase. It has been proposed as a possible chemotherapeutic agent in the treatment of brain metastases.
History
On May 9, 2006, a New Drug Application was submitted to the United States Food and Drug Administration by Pharmacyclics, Inc.In December 2007, the FDA issued a not approvable letter for motexafin gadolinium.