Mestranol/norethisterone

Mestranol/norethisterone is a combination of the estrogen estranol and the progestin norethisterone which was introduced in 1963 and was the second combined oral contraceptive to be marketed, following mestranol/noretynodrel in 1960. Although most mestranol-containing oral contraceptive formulations have been discontinued, the combination remains available today in the United States in a single formulation under the brand name Norinyl 1+50 28-Day. It has largely been superseded by ethinylestradiol/norethisterone, which has been marketed under many of the same brand names.