Melanie Blokesch
Melanie Blokesch is a German microbiologist. Her research focuses on Vibrio cholerae, the bacterium causing cholera. She is a professor of life sciences at École Polytechnique Fédérale de Lausanne, where she heads the Laboratory of Molecular Microbiology.
Career
Blokesch studied biology and microbiology at Ludwig Maximilian University of Munich where she received her diploma in 2000. She then joined August Böck's laboratory as a doctoral student and in 2004, graduated with her PhD awarded summa cum laude on "-Hydrogenases of Escherichia coli: Functions of Proteins involved in Metal Center Assembly". In 2005, she went to work as postdoctoral research fellow with Gary K. Schoolnik in the Division of Infectious Diseases and Geographic Medicine at Stanford University. In 2009, she became Assistant Professor in the Global Health Institute at École Polytechnique Fédérale de Lausanne, where she was promoted as Associate Professor in 2016 and Full Professor in 2021. Since 2009, she has been the director of the Laboratory of Molecular Microbiology.Research
Blokesch's research group investigates the pathogenic bacterium Vibrio cholerae that afflicts humans and has been responsible for major pandemics throughout history. She is interested how the natural environment of the bacterium is linked to its potential to evolve into a human pathogen.Her group studies how V. cholerae acquires new capabilities via horizontal gene transfer. They found the pilous fraction of the DNA-uptake machinery also enables the adherence to chitinous surfaces, such as exoskeleton of arthropods, also under conditions of water currents. Further they discovered that V. cholerae actively forages for DNA by killing neighboring cells via type VI secretion system while being able to spare kin cells. Thereby DNA chunks even beyond the length of 150kb are taken up and exchanged against regions of the bacterium's genome. They started also working on the HGT capabilities of Acinetobacter baumannii, another human pathogen, known for frequently being resistant to a variety of antibiotics, and mostly associated with high infection rates in hospital settings.
In order to better understand the interaction of host and pathogen, they also investigate routes of transmission in endemic cholera hot-spots. They discovered several virulence factors that might be used by V. cholerae in a Trojan horse-like manner to replicate in aquatic amoebae, and thereby could facilitate transmission.
The research of Blokesch and her group has been featured in international news outlets such as La Razón, Radio Télévision Suisse, The Times of India, National Geographic Magazine and Deutschlandfunk.