Mani began her apprenticeship with HAL in Balanagar shortly after receiving her diploma. She was summoned to the interview with ISRO. She received an appointment order to join the ISRO within three weeks after the interview. A team of ISRO scientists finished a 403-day expedition at Bharathi, India's Antarctic research station, in December 2018. Mani, who aged 56 at that time was the sole female on this team. She was part of a 23-person expedition crew. She ran and maintained the ground station from which 10 of the 14 orbits would be visible from Bharathi.