MPL
- Boost (C++ libraries)
- Computer multitasking
- MIDI
- MPL (gene)
- MPL Communications
- Maconomy
- Magnetic path length
- Malaysia Premier League
- Malian Party of Labour
- Maltese Premier League
- Mandatory Palestine League
- Mangalore Premier League
- Marfanoid–progeroid–lipodystrophy syndrome
- Marginal product of labor
- Markham Public Library
- Marple railway station
- Mars Polar Lander
- Matplotlib
- Max Planck Institute for the Science of Light
- Maximum parcel level
- Medial patellar luxation
- Memphis Public Library
- Messenger Plus! Live
- Mexican Pacific League
- Microsoft Public License
- Milton Public Library
- Milwaukee Public Library
- Minneapolis Public Library
- Minnesota Prairie Line
- Miyazaki Phoenix League
- Mobile Premier League
- Montpellier-Méditerranée Airport
- Movimento Passe Livre
- Mozilla Public License
- Mpls (disambiguation)
- Multi-crew pilot licence
- Multi-photon lithography
- PL/I
- Patrologia Latina
- Perl
- Puri Lukisan Museum
- Walther MP