James Little
James Little may refer to:
- James Little (American politician), Wisconsin State Assemblyman
- James Little (British politician), unionist politician in Northern Ireland
- James Little (physician), Irish physician
- James-Little Ecological Reserve
- Jimmy Little, Australian Aboriginal musician, singer and songwriter
- Jim Little (businessman), CEO of Ottawa Senators, 2020
- Jimmy Little (carpenter), carpenter, stagehand and TV personality
- James Little (shepherd), New Zealand shepherd and sheep breeder
- James Little (unionist), American labor union leader
- James Lewis Little, schooner captain and politician in Newfoundland
- James Little (painter), American painter