| Settlement | Founded, Relocated | Founders | Indians | Languages | Comments | Province | Coordinates | Image |
| San José de Chiquitos | 1698 | Felipe Suárez, Fr. Dionisio Ávila | Penoquis | Chiquitano | | Chiquitos Province | | |
| San Rafael de Velasco | 1695, 1701, 1705, 1719, 1750 | Juan Bautista Zea, Francisco Hervás | | Chiquitano | | José Miguel de Velasco Province | | |
| San Javier | 1691, 1696, 1698, 1708 | José de Arce, | Piñocas | Chiquitano | | Ñuflo de Chávez Province | | |
| San Miguel de Velasco | 1721 | Felipe Suárez, | | Migueleño Chiquitano | Founded because San Rafael was growing too big | José Miguel de Velasco Province | | |
| Concepción | 1699, 1707, 1708, 1722 | Francisco Lucas Caballero, Francisco Hervás | Chiquitanos | Chiquitano | | Ñuflo de Chávez Province | | |
| Santa Ana de Velasco | 1755 | Julian Knogler | Covarecas and Curuminacas | Otuke | | José Miguel de Velasco Province | | |
| San Ignacio de Velasco | 1748 | Diego Contreras, Michael Streicher | Ugaraños | Ignaciano Chiquitano | Partially settled by inhabitants of former San Ignacio de Zamucos | José Miguel de Velasco Province | | |
| San Juan Bautista | 1699, 1705 -closed, reopened in 1713 in a new location | Juan Bautista Zea, Juan Patricio Fernández | Suberecas, Petas, Piñocas | Chiquitano | Founded because San José had grown too big | Chiquitos Province | | |
| San Ignacio de Zamucos | 1716, 1723; abandoned in 1745 | Felipe Suárez, Juan Bautista Zea, Agustín Castañares | | Ayoreo | | Cordillera Province | | |
| Santo Corazón | 1760, 1788 | Antonio Gaspar, José Chueca | Otukes | Otuke | | Ángel Sandoval Province | | |
| Santiago de Chiquitos | 1754, 1764 | Gaspar Troncoso, Gaspar Campos | | Santiagueño Chiquitano | | Chiquitos Province | | |