List of highways numbered 281
The following highways are numbered 281:
Canada
Japan
United States
- U.S. Route 281
- Alabama State Route 281
- Arkansas Highway 281
- California State Route 281
- Florida [State Road 281]
- Georgia State Route 281
- Iowa Highway 281
- Kentucky Route 281
- Maryland Route 281
- Minnesota State Highway 281
- Montana Secondary Highway 281
- New Mexico State Route 281
- New York State Route 281
- North Carolina Highway 281
- North Dakota Highway 281
- Ohio State Route 281
- Oklahoma State Highway 281A
- Oregon Route 281
- Pennsylvania Route 281
- South Carolina Highway 281
- Tennessee State Route 281
- Texas State Highway 281
- * Texas State Highway Loop 281
- * Farm to Market Road 281
- Utah State Route 281
- Washington State Route 281