| Name | Source | Type |
| Earth people | Doraemon | Humanoids who are gender-swapped version of Earth people |
| Eber | 2300 AD | |
| Ectonurite | Ben 10 | Cycloptic ghost-like aliens from the skeletal planet Anur Phaetos, who have powers similar to ghosts in culture, including invisibility, intangibility, and possessing the bodies of others. Furthermore, they commonly wear a secondary skin that condenses their form and conceals their monstrous appearance. |
| Edestekai | Star Frontiers | trilaterally symmetrical nomads |
| Edo | Star Trek | |
| Ekhonides | Perry Rhodan | |
| Ekoplektoid | Ben 10 | A humanoid frog-like race from planet Ekoplekton, a sprawling metropolis that continues growing due to their rapid rate their population grows. This high rate, however, is not due to reproductive capabilities, but their main ability: if they sustain a hit to their back, they involuntarily split into two clones that are half the size of the original, but are twice as heavy, dense, and strong. |
| El-Aurians | Star Trek | Humanoid race of "listeners" |
| Elcor | Mass Effect | Large, heavy, quadruped. Slow to act, have to directly state emotions. |
| Eldar | Warhammer 40,000 | Humanoid |
| Elder Gods | Cthulhu Mythos | |
| Elder Thing | Cthulhu Mythos | |
| Eldorians | Utopia | |
| Electrogoomba | Super Mario Galaxy | Evolved species of a Goomba, the species is divided into different variants |
| Elerians | Master of Orion II | Humanoid |
| Elites | Halo | Technologically superior race of military supremacy. Mainstay of Covenant military until philosophical differences removed them from the Hierarchy. They allied themselves to humans to combat the Covenant. Uncertain allies to humans. |
| Ellimist | K. A. Applegate's Animorphs | All powerful being with no known appearance |
| Elves | Bravest Warriors | These creatures are nearly all virtual except for Wankershim, who exited the Holo John and became a separate life form. Wankershim, however, then enveloped the whole universe. |
| Elvis | Perfect Dark | Grey |
| Elgyem | Pokémon | - |
| Engineers | Halo | Maintain Halo Rings, but are not officially part of the Covenant. Large, pink, squid like creatures. No real threat to Humanity other than maintaining the Halo Rings, which are a threat to humanity. |
| Engineers | Prometheus (2012 film) | 9 ft. tall pale white muscular humanoids, the supposed genetic originators of humankind. |
| Eoladi | Master of Orion III | |
| Eorna | Star Frontiers | Highly advanced reptilians facing extinction |
| Eosapien | Alien Planet | |
| Ep-Hogers | Perry Rhodan | |
| Eppori | Harry Turtledove's Worldwar series | An animal native to Home. Its appearance was described resembling "a cross between a zebra and a duckbilled dinosaur" striped in a pattern of gold and dark brown. It was domesticated by the [The The Race (Worldwar)|Race (Worldwar)|Race] early in its history and was used as a riding animal and beast of burden. With the advent of mechanized vehicles, the eppori in Race society was mostly rendered obsolete. However, they continued to be used by zisuili farmers and others for attraction. |
| Erg | Hyperion Cantos | Silicon-based life forms |
| Eridani | Battlelords of the 23rd Century | Humanoid |
| Eschiff | London Wild | Feline Humanoid |
| Esmers | Little Big Adventure 2 | |
| Esperians | Star Fleet | Humanoid |
| E.T. | E.T. the Extra-Terrestrial | |
| Eternians | Masters of the Universe franchise | |
| Ethereals | X-COM: UFO Defense | Alien with telepathic powers capable of breaking the laws of physics and manipulating other beings to do their bidding. Even through their bodies should not be able to keep them alive as they have no functioning organs they can still live. |
| Ethereans | Masters of the Universe franchise | There are a number of different species on the planet Etherea from shows such as She-Ra and the Princesses of Power, including humanoids, but they are not explicitly stated to be humans. |
| Exocomp | Star Trek | Exocomps were industrial and utility robots designed by the Tyran Doctor Farallon that later gained sentience. |
| Extraterrestrial Biological Entities | The Event | Aliens that strongly resemble humans by 99%. They have enhanced lifespans, meaning they age at a slow rate. |
| Exquivan | Star Control 3 | |
| Extraterrestrial Living-metal Shape-shifter | Mobile Suit Gundam 00 the Movie: Awakening of the Trailblazer | |
| Evon | Master of Orion III | Humanoid |
| Evroniani | PKNA - Paperinik New Adventure | Duck-like humanoid |
| Ewoks | Star Wars | Small furry humanoids |
| Experiments | Lilo & Stitch | Artificial alien species with widely varying body types and abilities all created by Kweltikwan mad scientist Dr. Jumba Jookiba. All such creatures are sentient, but were all programmed to cause mischief until their rehabilitation by Lilo Pelekai and Stitch, the latter who is among them and was also the first to be rehabilitated by Lilo. |
| Eywa | James Cameron's Avatar | Deity / Neural connection between trees |