List of banned substances in Major League Baseball


Major League Baseball's drug policy prohibits players from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse and/or Steroid. Any and all drugs or substances listed under Schedule II of the Controlled Substances Act are considered drugs of abuse covered by the Program. Players who require prescription medication can still use it with a "Therapeutic Use Exemption" granted by MLB.
In December 2019, MLB removed cannabinoids and added cocaine and opiates to its list of Drugs of Abuse. However, players were told that they could still be suspended for possessing or selling cannabis, or driving under the influence of cannabis.

List of banned substances (not exhaustive)

Sources:

Drugs of abuse

  1. Synthetic cannabinoids
  2. Cocaine
  3. LSD
  4. Opiates
  5. Amphetamines
  6. "Bath salts"
  7. GHB
  8. Phencyclidine

Performance enhancing substances (steroids, growth factors, hormone modulators, masking agents)

  1. Androstanediol
  2. Androstanedione
  3. Androstatrienedione
  4. Androstanolone
  5. Androstenediol
  6. Androstenedione
  7. Androst-2-en-17-one
  8. Androsterone
  9. Bolandiol
  10. Bolasterone
  11. Boldenone
  12. Boldione
  13. Calusterone
  14. Clenbuterol
  15. Clostebol
  16. Danazol
  17. Dehydrochloromethyltestosterone
  18. Dehydroepiandrosterone
  19. Desoxy-methyltestosterone
  20. Dihydrotestosterone
  21. Drostanolone
  22. Epiandrosterone
  23. Epi-dihydrotestosterone
  24. Epitestosterone
  25. Ethylestrenol
  26. Fluoxymesterone
  27. Formebolone
  28. Furazabol
  29. Gestrinone
  30. Halodrol
  31. 4-Hydroxytestosterone
  32. 7-Keto-DHEA
  33. Mestanolone
  34. Mesterolone
  35. Methandienone
  36. Methandriol
  37. Methasterone
  38. Methenolone
  39. Methylclostebol
  40. Methyldienolone
  41. Methylnortestosterone
  42. Methylstenbolone
  43. Methyltestosterone
  44. Methyltrienolone
  45. Mibolerone
  46. Nandrolone
  47. Norbolethone
  48. Norandrostenediol
  49. Norandrostenedione
  50. Norandrosterone
  51. Norbolethone
  52. Norclostebol
  53. Norethandrolone
  54. Noretiocholanolone
  55. Oxabolone
  56. Oxandrolone
  57. Oxymesterone
  58. Oxymetholone
  59. Prasterone
  60. Promagnon
  61. Prostanozol
  62. Quinbolone
  63. Selective androgen receptor modulators
  64. Stanozolol
  65. Stenbolone
  66. Testosterone
  67. Tetrahydrogestrinone
  68. Tibolone
  69. Trenbolone
  70. Zeranol
  71. Zilpaterol
  72. Any salt, ester, or ether of a drug or substance listed above
  73. Human growth hormone, including all fragments and releasing factors including GHRHs, GHSs, including all isomers of IGF-1
  74. Gonadotrophins, including LH and hCG
  75. Corticotrophins, including releasing factors
  76. Erythropoiesis stimulating agents, including, darbepoetin, hematide, methoxy polyethylene glycol-epoetin beta )
  77. Aromatase inhibitors, including anastrozole, androstatrienedione, androstenetrione, aminoglutethimide, arimistane, exemestane, formestane, letrozole, and testolactone
  78. Selective estrogen receptor modulators, including bazedoxifene, ospemifene, raloxifen, tamoxifen, and toremifen
  79. Other Anti-estrogens, including clomiphene, cyclofenil, and fulvestrant
  80. Myostatin modifying agents, including myostatin inhibitors
  81. Metabolic modifying agents, including Peroxisome Proliferator Activated Receptor δ agonists, AMP-activated protein kinase activators, meldonium, trimetazidine
  82. HIF stabilizers, including roxadustat, molidustat, FG-2216, BAY 87-2243.
  83. Masking agents, including diuretics, desmopressin, probenecid, plasma expanders
  84. Diuretics include acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides, triamterene, vaptans
  85. Gene doping, the use of nucleic acids that may alter genome sequences and/or gene expression, including gene editing, gene silencing, gene transfer, genetically modified cells

Stimulants

  1. Adrafinil
  2. Amfepramone
  3. Amiphenazole
  4. Amphetamine
  5. Amphetaminil
  6. Armodafinil
  7. Benfluorex
  8. Benzphetamine
  9. Benzylpiperazine
  10. Bromantan
  11. Carphedon
  12. Cathine
  13. Chloroamphetamine
  14. Clobenzorex
  15. Cropropamide
  16. Crotetamide
  17. Dimethylamylamine
  18. Dimethylamphetamine
  19. 1,3-Dimethylbutylamine
  20. Ephedrine
  21. Etamivan
  22. Ethylamphetamine
  23. Etilefrine
  24. Famprofazone
  25. Fenbutrazate
  26. Fencamfamine
  27. Fenethylline
  28. Fenfluramine
  29. Fenproporex
  30. Furfenorex
  31. Heptaminol
  32. Isometheptene
  33. Levmetamphetamine
  34. Lisdexamphetamine
  35. Meclofenoxate
  36. Mefenorex
  37. Mephentermine
  38. Mesocarb
  39. Methylephedrine
  40. Methylhexaneamine
  41. Methylphenidate
  42. Modafinil
  43. N,alpha-Diethylphenylethylamine
  44. N-ethyl-1-phenyl-2-butanamine
  45. Nikethamide
  46. Norfenefrine
  47. Norfenfluramine
  48. Octodrine
  49. Octopamine
  50. Oxilofrine
  51. Parahydroxyamphetamine
  52. Pemoline
  53. Pentetrazol
  54. Phendimetrazine
  55. Phenethylamine
  56. Phenmetrazine
  57. Phenpromethamine
  58. Phentermine
  59. Prenylamine
  60. Prolintane
  61. Propylhexedrine
  62. Pyrovalerone
  63. Selegiline
  64. Sibutramine
  65. Strychnine
  66. Tuaminoheptane
Prohibited Substances may be added to the list only by the unanimous vote of HPAC, provided that the addition by the federal government of a substance to Schedule I, II, or III will automatically result in that substance being added to the list.