Norfenefrine
Norfenefrine, also known as meta-octopamine or norphenylephrine and sold under the brand name Novadral among others, is a sympathomimetic medication which is used in the treatment of hypotension. Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.
Medical uses
Norfenefrine is used in the treatment of hypotension. It is said to be similarly effective or less effective than midodrine.Pharmacology
Pharmacodynamics
Norfenefrine is described as an α-adrenergic receptor agonist and sympathomimetic agent. It is said to act predominantly as an α1-adrenergic receptor agonist.Chemistry
Norfenefrine, also known as 3,β-dihydroxyphenethylamine, is a substituted phenethylamine derivative. It is an analogue of norepinephrine, of meta-tyramine, of phenylephrine, of etilefrine, and of metaterol, as well as of metaraminol.Norfenefrine is used medically as the hydrochloride salt.
The predicted log P of norfenefrine is -0.28 to -0.95.