List of airlines with more than 100 destinations
This list only contains airlines that fly passengers to over 100 destinations, excluding defunct airlines.
| Airline | Number of destinations | Remarks | Country of origin |
| United Airlines | 373 | ||
| American Airlines | 353 | ||
| Delta Air Lines | 311 | ||
| Lion Air | 307 | including Batik Air, Batik Air Malaysia, Super Air Jet, Thai Lion Air, Lion Air, Wings Air | |
| Turkish Airlines | 286 | ||
| Ryanair | 239 | including Ryanair DAC, Malta Air, Buzz, Ryanair UK and Lauda | |
| China Southern Airlines | 235 | ||
| Lufthansa | 229 | Including Lufthansa Regional | |
| China Eastern Airlines | 226 | ||
| British Airways | 213 | ||
| Air China | 203 | ||
| Wizz Air | 200 | including Wizz Air Hungary, Wizz Air Malta and Wizz Air UK | |
| Qatar Airways | 198 | ||
| Air France | 196 | ||
| Air Canada | 192 | ||
| EasyJet | 183 | Including EasyJet Switzerland | |
| AirAsia | 166 | Total of AirAsia Group | |
| KLM | 164 | ||
| Azul Brazilian Airlines | 163 | Including Azul Conecta | |
| Ethiopian Airlines | 161 | ||
| Eurowings | 152 | ||
| Emirates | 152 | ||
| Singapore Airlines | 144 | Includes Scoot |  SingaporeCHNESPTURUSAINDDNKNORSWEUAEUSAAUTCHEGRCUSAUSACHNKORMORNORCANRUSCHNFINAUSCHNCHNCHNEGY |