List of US Open mixed doubles champions
The following pairings won the U.S. Open tennis championship in mixed doubles.
2025 format change
In 2025 there was a big format change. The tournament took place over two days with the Final being played before day one of the US Open.The matches were being played in best-of-three-sets with short sets to four games, no-ad scoring, tiebreakers at four-all, and a 10-point match tiebreak in lieu of a third set. The final was a best-of-three set match to six games, featuring no-ad scoring, with tiebreakers at six-all with a 10-point match tiebreaker in lieu of a third set.
Finals
U.S. National Championships
| † Unofficial event that did not carry championship status. |
| Year | Champions | Runners-up | Score |
| 1887 |  |1877 |